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Who was studied 4,961 Chinese ancestry cases, 69,084 Chinese ancestry controls; replicated in 38,266 Chinese ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.328 higher (95% confidence interval 0.23-0.42); p = 1 × 10−11.
How common The A allele had a frequency of about 25% in the people studied.
What each result means
A/ATwo copies of the version the research linked to Subclinical hypothyroidism in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Subclinical hypothyroidism in pregnancy. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Subclinical hypothyroidism in pregnancy. This is the starting point the study compared everyone against.
rs74678088 is a single position in the genome, in or near the VAV3 gene. Published research associates it with subclinical hypothyroidism in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74678088 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs74678088 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74678088 come from?
GWAS Catalog, Nature genetics 2026, PMID:42509370. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 33Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others3Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Subclinical hypothyroidism in pregnancy (rs74678088). MyGeneLog™. https://www.mygenelog.com/variants/rs74678088