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Who was studied 291,512 European ancestry individuals, 5,007 African ancestry individuals, 6,088 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0652 lower (95% confidence interval 0.045-0.085); p = 1 × 10−10.
Where it sits Chromosome 2, band 2q37.1 — in an intron of UGT1A9.
What each result means
A/ANo copy of the version the research linked to Direct bilirubin levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Direct bilirubin levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Direct bilirubin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs74669452
What is rs74669452?
rs74669452 is a single position in the genome, in or near the UGT1A9 gene. Published research associates it with direct bilirubin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74669452 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs74669452 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74669452 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7214Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Direct bilirubin levels (rs74669452). MyGeneLog™. https://www.mygenelog.com/variants/rs74669452