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Glucose-dependent insulinotropic peptide levels

near SLC24A4 · rs746586

What the study found

Who was studied 1,907 Sub-Saharan African ancestry individuals; replicated in 1,653 African American individuals.

The effect Each copy of the T allele shifted the measure 0.544 lower (95% confidence interval 0.38-0.71); p = 2 × 10−10.

Where it sits Chromosome 14, band 14q32.12 — between genes, 13 kb from SLC24A4.

What each result means

C/C No copy of the version the research linked to Glucose-dependent insulinotropic peptide levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Glucose-dependent insulinotropic peptide levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Glucose-dependent insulinotropic peptide levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs746586

What is rs746586?

rs746586 is a single position in the genome, in or near the near SLC24A4 gene. Published research associates it with glucose-dependent insulinotropic peptide levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs746586 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs746586 come from?

GWAS Catalog, Genome medicine 2021, PMID:34620218. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glucose-dependent insulinotropic peptide levels (rs746586). MyGeneLog™. https://www.mygenelog.com/variants/rs746586

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