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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 38,000 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.136 lower (95% confidence interval 0.097-0.175); p = 1 × 10−11.
Where it sits Chromosome 5, band 5p13.1 — in an intron of PRKAA1.
What each result means
C/CNo copy of the version the research linked to Urea levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Urea levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Urea levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39414775 · open access
Questions about rs74653842
What is rs74653842?
rs74653842 is a single position in the genome, in or near the PRKAA1 gene. Published research associates it with urea levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs74653842 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74653842 come from?
GWAS Catalog, Nature communications 2024, PMID:39414775. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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