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Who was studied 4,125 European ancestry cases, 20,464 European ancestry controls.
The effect
Each copy of the A allele carried 1.49 times the odds of Idiopathic pulmonary fibrosis (95% confidence interval 1.33-1.67); p = 3 × 10−12.
How common The A allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 16, band 16p13.3 — in an intron of NPRL3.
What each result means
A/ATwo copies of the version the research linked to Idiopathic pulmonary fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Idiopathic pulmonary fibrosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Idiopathic pulmonary fibrosis. This is the starting point the study compared everyone against.
rs74614704 is a single position in the genome, in or near the NPRL3 gene. Published research associates it with idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74614704 linked to?
On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs74614704 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74614704 come from?
GWAS Catalog, Thorax 2022, PMID:35688625. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 51112Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple1China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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