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Cholesterol esters in very large HDL

ETV5 · rs74607912

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 7 × 10⁻¹⁹.

Where it sits Chromosome 3, band 3q27.2 — in an intron of ETV5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol esters in very large HDL compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol esters in very large HDL.

G/G Published research associates this genotype with typical/baseline likelihood of Cholesterol esters in very large HDL — no copies of the reported risk allele.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs74607912

What is rs74607912?

rs74607912 is a single position in the genome, in or near the ETV5 gene. Published research associates it with cholesterol esters in very large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74607912 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs74607912 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74607912 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesterol esters in very large HDL (rs74607912). MyGeneLog™. https://www.mygenelog.com/variants/rs74607912

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