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White blood cell count

EHD4 · rs74587848

What the study found

Who was studied 153,950 Korean ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0428 lower (95% confidence interval 0.03-0.056); p = 8 × 10−11.

How common The C allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 15, band 15q15.1 — in an intron of EHD4.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White blood cell count compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White blood cell count.
T/T Published research associates this genotype with typical/baseline likelihood of White blood cell count — no copies of the reported risk allele.
Source

Questions about rs74587848

What is rs74587848?

rs74587848 is a single position in the genome, in or near the EHD4 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74587848 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74587848 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White blood cell count (rs74587848). MyGeneLog™. https://www.mygenelog.com/variants/rs74587848

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