Sensitive

Cervical cancer

HPVC1 · rs7457728

Where this position leads

Condition: Cervical Cancer

rs7457728 Condition: Cervical Cancer Cervical Cancer Condition rs7457728 rs7457728 HPVC1

What the study found

Who was studied 2,609 East Asian ancestry cases, 4,712 East Asian ancestry controls; replicated in 1,461 Han Chinese ancestry cases, 3,295 Han Chinese ancestry controls.

The effect Each copy of the C allele carried 1.19 times the odds of Cervical cancer; p = 1 × 10−8.

How common The C allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 7, band 7p11.2 — in an intron of LINC01445.

What each result means

C/C Two copies of the version the research linked to Cervical cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Cervical cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Cervical cancer. This is the starting point the study compared everyone against.
Source

Questions about rs7457728

What is rs7457728?

rs7457728 is a single position in the genome, in or near the HPVC1 gene. Published research associates it with cervical cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7457728 linked to?

On MyGeneLog this position is linked to Cervical Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7457728 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7457728 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30412241. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cervical cancer (rs7457728). MyGeneLog™. https://www.mygenelog.com/variants/rs7457728

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