Standard

Uterine fibroids

DEPDC5 · rs74555131

Where this position leads

What the study found

Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls, 14,905 East Asian ancestry female cases, 69,609 East Asian ancestry female controls, 14,905 Central Asian ancestry female cases, 69,609 Central Asian ancestry female controls, 14,905 South Asian ancestry female cases, 69,609 South Asian ancestry female controls, 5,678 African ancestry female cases, 15,760 African ancestry female controls.

The effect Each copy of the A allele shifted the measure 0.153 higher (95% confidence interval 0.11-0.2); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 22, band 22q12.3 — in an intron of DEPDC5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Uterine fibroids compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Uterine fibroids.

G/G Published research associates this genotype with typical/baseline likelihood of Uterine fibroids — no copies of the reported risk allele.

Source

Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups

Kim J, Williams A, Noh H, Jasper EA, Jones SH, Jaworski JA, Shuey MM, Ruiz-Narváez EA, Wise LA, Palmer JR, Connolly J, Keaton JM

and 11 more — show all

Denny JC, Khan A, Abbass MA, Rasmussen-Torvik LJ, Kottyan LC, Madhivanan P, Krupp K, Wei WQ, Edwards TL, Velez Edwards DR, Hellwege JN

Nature communications · 2025 · PMID 40050615 · open access

Questions about rs74555131

What is rs74555131?

rs74555131 is a single position in the genome, in or near the DEPDC5 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74555131 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs74555131 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74555131 come from?

GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Uterine fibroids (rs74555131). MyGeneLog™. https://www.mygenelog.com/variants/rs74555131

← See all variants