MPZL2 · rs74543584
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 121,934 European ancestry cases, 591,699 European ancestry controls.
The effect Each copy of the A allele carried 4.79 times the odds of Age-related hearing impairment; p = 1 × 10−8.
How common The A allele had a frequency of about 83% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — a missense change in MPZL2.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for MPZL2-related disorder, Hearing loss, autosomal recessive 111, Clear cell carcinoma of kidney, Colon adenocarcinoma; criteria provided, conflicting classifications (1 of 4 stars, 6 submitters), last evaluated 2026-01-01.
ClinVar record 2578670 NM_005797.4(MPZL2):c.278A>T (p.Asp93Val)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs74543584 is a single position in the genome, in or near the MPZL2 gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2021, PMID:34108613. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Age-related hearing impairment (rs74543584). MyGeneLog™. https://www.mygenelog.com/variants/rs74543584