Standard
Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase
HLA-DQA2 · rs7454108
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase.
T/T
Published research associates this genotype with typical/baseline likelihood of Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase — no copies of the reported risk allele.
Source
Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Merkel PA,
Xie G,
Monach PA,
Ji X,
Ciavatta DJ,
Byun J,
Pinder BD,
Zhao A,
Zhang J,
Tadesse Y,
Qian D,
Weirauch M
and 32 more — show all
Nair R,
Tsoi A,
Pagnoux C,
Carette S,
Chung S,
Cuthbertson D,
Davis JC Jr,
Dellaripa PF,
Forbess L,
Gewurz-Singer O,
Hoffman GS,
Khalidi N,
Koening C,
Langford CA,
Mahr AD,
McAlear C,
Moreland L,
Seo EP,
Specks U,
Spiera RF,
Sreih A,
St Clair EW,
Stone JH,
Ytterberg SR,
Elder JT,
Qu J,
Ochi T,
Hirano N,
Edberg JC,
Falk RJ,
Amos CI,
Siminovitch KA
Arthritis & rheumatology (Hoboken, N.J.) · 2017 · PMID 28029757 · open access
Questions about rs7454108
What is rs7454108?
rs7454108 is a single position in the genome, in or near the HLA-DQA2 gene. Published research associates it with vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7454108 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7454108 come from?
GWAS Catalog, Arthritis Rheumatol 2016, PMID:28029757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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