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CD3 on naive CD8+ T cell

CD247 · rs74524218

What the study found

Who was studied 2,910 Sardinian (founder/genetic isolate) ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.41 higher (95% confidence interval 0.33-0.49); p = 4 × 10−22.

How common The C allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — in an intron of CD247.

What each result means

C/C Two copies of the version the research linked to CD3 on naive CD8+ T cell. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to CD3 on naive CD8+ T cell. That is a smaller link than two copies.
T/T No copy of the version the research linked to CD3 on naive CD8+ T cell. This is the starting point the study compared everyone against.
Source

Questions about rs74524218

What is rs74524218?

rs74524218 is a single position in the genome, in or near the CD247 gene. Published research associates it with cd3 on naive cd8+ t cell. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74524218 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74524218 come from?

GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CD3 on naive CD8+ T cell (rs74524218). MyGeneLog™. https://www.mygenelog.com/variants/rs74524218

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