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Cerebrospinal fluid protein ADGRB3 levels

COL19A1 · rs74488411

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,524 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.389 higher (95% confidence interval 0.3-0.48); p = 4 × 10⁻¹⁶.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 6, band 6q13 — in an intron of COL19A1.

What each result means

A/A Two copies of the version the research linked to Cerebrospinal fluid protein ADGRB3 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/C One copy of the version the research linked to Cerebrospinal fluid protein ADGRB3 levels. That is a smaller link than two copies.

C/C No copy of the version the research linked to Cerebrospinal fluid protein ADGRB3 levels. This is the starting point the study compared everyone against.

Source

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I

and 12 more — show all

Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C

Science translational medicine · 2026 · PMID 42054495

Questions about rs74488411

What is rs74488411?

rs74488411 is a single position in the genome, in or near the COL19A1 gene. Published research associates it with cerebrospinal fluid protein adgrb3 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74488411 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74488411 come from?

GWAS Catalog, Science translational medicine 2026, PMID:42054495. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid protein ADGRB3 levels (rs74488411). MyGeneLog™. https://www.mygenelog.com/variants/rs74488411

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