ABCC1 · rs74475935
Where this position leads
Condition: Ischaemic Stroke
What the study found
Who was studied up to 8,062 European ancestry cases, up to 1,086 African ancestry cases, up to 362 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls; replicated in 17 African ancestry cases, 17 East Asian ancestry cases, 3,514 European ancestry cases, 149 Hispanic cases, 239 African ancestry controls, 329 East Asian ancestry controls, 259,291 European ancestry controls, 686 Hispanic controls.
The effect Each copy of the G allele carried 4.63 times the odds of Ischemic stroke (undetermined subtype) (95% confidence interval 2.77-7.72); p = 5 × 10−11.
How common The G allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 16, band 16p13.11 — in an intron of ABCC1.
rs74475935 is a single position in the genome, in or near the ABCC1 gene. Published research associates it with ischemic stroke (undetermined subtype). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Lancet Neurol 2015, PMID:26708676. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Ischemic stroke (undetermined subtype) (rs74475935). MyGeneLog™. https://www.mygenelog.com/variants/rs74475935