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Who was studied 2,270 African ancestry cases, 207,823 African ancestry controls.
The effect
Each copy of the G allele shifted the measure 1.79 higher (95% confidence interval 1.18-2.41); p = 1 × 10−8.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 4, band 4q32.1 — in an intron of RAPGEF2.
What each result means
A/ANo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs74461205
What is rs74461205?
rs74461205 is a single position in the genome, in or near the RAPGEF2 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74461205 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs74461205 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74461205 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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