3 1817217Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot0Amazon2Apple1Others7Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 305 European ancestry cognitively normal individuals.
The effect
Each copy of the G allele shifted the measure 1.02 lower (95% confidence interval 0.67-1.37); p = 3 × 10−8.
How common The G allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 12, band 12p13.1 — in an intron of GRIN2B.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Cerebrospinal AB1-42 levels in normal cognition — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cerebrospinal AB1-42 levels in normal cognition.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cerebrospinal AB1-42 levels in normal cognition compared to the general population.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018 · PMID 29274321
Questions about rs74442473
What is rs74442473?
rs74442473 is a single position in the genome, in or near the GRIN2B gene. Published research associates it with cerebrospinal ab1-42 levels in normal cognition. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs74442473 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74442473 come from?
GWAS Catalog, Alzheimers Dement 2017, PMID:29274321. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 1817217Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot0Amazon2Apple1Others7Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cerebrospinal AB1-42 levels in normal cognition (rs74442473). MyGeneLog™. https://www.mygenelog.com/variants/rs74442473