2 3618123120Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 18,719 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,441,938 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the T allele shifted the measure 0.312 lower (95% confidence interval 0.2-0.42); p = 3 × 10−8.
How common The T allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 14, band 14q24.1 — in an intron of RAD51B.
What each result means
C/CNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs74435447
What is rs74435447?
rs74435447 is a single position in the genome, in or near the RAD51B gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74435447 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs74435447 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74435447 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 3618123120Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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