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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 406,504 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0311 higher; p = 3 × 10−14.
Where it sits Chromosome 1, band 1p36.12 — between genes, 1 kb from ZNF436.
What each result means
G/GTwo copies of the version the research linked to Estimated glomerular filtration rate (creatinine). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Estimated glomerular filtration rate (creatinine). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Estimated glomerular filtration rate (creatinine). This is the starting point the study compared everyone against.
rs74416781 is a single position in the genome, in or near the near ZNF436 gene. Published research associates it with estimated glomerular filtration rate (creatinine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs74416781 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74416781 come from?
GWAS Catalog, Nature genetics 2024, PMID:39256582. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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