Standard

Reasoning

LOC102724945 · rs74412765

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2 Alaskan native ancestry schizophrenia cases, 18 Asian ancestry schizophrenia cases, 20 African American schizophrenia cases, 1 Native Hawaiian ancestry schizophrenia cases, 86 European ancestry schizophrenia cases, 2 Alaskan native ancestry controls, 10 Asian ancestry controls, 17 African American controls, 1 Native Hawaiian ancestry controls, 106 European ancestry controls.

The effect Each copy of the T allele shifted the measure 1.7 lower; p = 3 × 10⁻⁸.

Where it sits Chromosome 14, band 14q13.1 — in an intron of EGLN3-AS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Reasoning — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Reasoning.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Reasoning compared to the general population.

Source

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

Nakahara S, Medland S, Turner JA, Calhoun VD, Lim KO, Mueller BA, Bustillo JR, O'Leary DS, Vaidya JG, McEwen S, Voyvodic J, Belger A

and 6 more — show all

Mathalon DH, Ford JM, Guffanti G, Macciardi F, Potkin SG, van Erp TGM

Schizophrenia research · 2018 · PMID 29907492

Questions about rs74412765

What is rs74412765?

rs74412765 is a single position in the genome, in or near the LOC102724945 gene. Published research associates it with reasoning. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74412765 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74412765 come from?

GWAS Catalog, Schizophr Res 2018, PMID:29907492. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Reasoning (rs74412765). MyGeneLog™. https://www.mygenelog.com/variants/rs74412765

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