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Creatinine levels

PKD1 · rs74331768

Where this position leads

Condition: Kidney Function

rs74331768 Condition: Kidney Function Kidney Function Condition rs74331768 rs74331768 PKD1

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 mmol/L higher (95% confidence interval 0.02-0.02); p = 1 × 10−12.

Where it sits Chromosome 16, band 16p13.3 — a synonymous change in PKD1.

What ClinVar records

Classification Benign for Polycystic kidney disease, adult type, Autosomal dominant polycystic kidney disease, Polycystic kidney disease; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 11 submitters), last evaluated 2025-03-27. ClinVar record 256950 NM_001009944.3(PKD1):c.3375C>T (p.Ser1125=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Creatinine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Creatinine levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Creatinine levels. This is the starting point the study compared everyone against.
Source
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C
Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs74331768

What is rs74331768?

rs74331768 is a single position in the genome, in or near the PKD1 gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74331768 linked to?

On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.

Does having rs74331768 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74331768 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Creatinine levels (rs74331768). MyGeneLog™. https://www.mygenelog.com/variants/rs74331768

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