0 1412218Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 6,861 African American or Afro-Caribbean cases, 48,644 African American or Afro-Caribbean controls, 2,207 Hispanic or Latin American cases, 27,107 Hispanic or Latin American controls, 329 East Asian ancestry cases, 3,218 East Asian ancestry controls, 20,090 European ancestry cases, 295,578 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 1.14 lower (95% confidence interval 1.09-1.2); p = 3 × 10−31.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 1, band 1q24.3 — a stop-gain change in MYOCOS.
What ClinVar records
ClassificationPathogenic for Glaucoma 1, open angle, A, Primary open angle glaucoma, Open-angle glaucoma, MYOC-related disorder; reviewed by expert panel (3 of 4 stars, 19 submitters), last evaluated 2026-01-12.
ClinVar record 7949NM_000261.2(MYOC):c.1102C>T (p.Gln368Ter)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Glaucoma. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Glaucoma. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Glaucoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs74315329
What is rs74315329?
rs74315329 is a single position in the genome, in or near the MYOCOS gene. Published research associates it with glaucoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74315329 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs74315329 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74315329 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1412218Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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