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Serum metabolite levels

ALMS1 · rs7424690

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,926 Hispanic/Latino individuals.

The effect Each copy of the T allele shifted the measure 0.652 lower (95% confidence interval 0.6-0.7); p = 6 × 10⁻¹⁴⁴.

How common The T allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 2, band 2p13.1 — in an intron of ALMS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Serum metabolite levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum metabolite levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum metabolite levels compared to the general population.

Source

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

Feofanova EV, Chen H, Dai Y, Jia P, Grove ML, Morrison AC, Qi Q, Daviglus M, Cai J, North KE, Laurie CC, Kaplan RC

and 2 more — show all

Boerwinkle E, Yu B

American journal of human genetics · 2020 · PMID 33031748

Questions about rs7424690

What is rs7424690?

rs7424690 is a single position in the genome, in or near the ALMS1 gene. Published research associates it with serum metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7424690 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7424690 come from?

GWAS Catalog, Am J Hum Genet 2020, PMID:33031748. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum metabolite levels (rs7424690). MyGeneLog™. https://www.mygenelog.com/variants/rs7424690

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