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Cholesterol, total

APOE · rs7412

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Drug: Lecanemab and other anti-amyloid antibodies

rs7412 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Drug: Lecanemab and other anti-amyloid antibodies Lecanemab and other anti-amyloid an… Drug rs7412 rs7412 APOE

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Cholesterol, total — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol, total.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol, total compared to the general population.
Source
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
Nagy R, Boutin TS, Marten J, Huffman JE, Kerr SM, Campbell A, Evenden L, Gibson J, Amador C, Howard DM, Navarro P, Morris A
and 13 more — show all
Deary IJ, Hocking LJ, Padmanabhan S, Smith BH, Joshi P, Wilson JF, Hastie ND, Wright AF, McIntosh AM, Porteous DJ, Haley CS, Vitart V, Hayward C
Genome medicine · 2017 · PMID 28270201 · open access

What people read about alongside this

Vitamins and nutrient levels1 Skin, sun and hair1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7412

What is rs7412?

rs7412 is a single position in the genome, in or near the APOE gene. Published research associates it with cholesterol, total. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7412 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does rs7412 affect how medicines work?

APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs7412?

Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (1 papers), skin, sun and hair (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7412 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7412 come from?

GWAS Catalog, Genome Med 2017, PMID:28270201. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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