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White blood cell count (neutrophil)

near HMGB3P6 · rs74117915

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,201 African American or Afro-Caribbean individuals.

The effect Each copy of the A allele shifted the measure 0.115 higher (95% confidence interval 0.08-0.151); p = 2 × 10−10.

How common The A allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — between genes, 22 kb from HMGB3P6.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White blood cell count (neutrophil) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White blood cell count (neutrophil).
G/G Published research associates this genotype with typical/baseline likelihood of White blood cell count (neutrophil) — no copies of the reported risk allele.
Source
Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study
Hu Y, Bien SA, Nishimura KK, Haessler J, Hodonsky CJ, Baldassari AR, Highland HM, Wang Z, Preuss M, Sitlani CM, Wojcik GL, Tao R
and 22 more — show all
Graff M, Huckins LM, Sun Q, Chen MH, Mousas A, Auer PL, Lettre G, Tang W, Qi L, Thyagarajan B, Buyske S, Fornage M, Hindorff LA, Li Y, Lin D, Reiner AP, North KE, Loos RJF, Raffield LM, Peters U, Avery CL, Kooperberg C
Blood Cell Consortium
BMC genomics · 2021 · PMID 34107879 · open access

Questions about rs74117915

What is rs74117915?

rs74117915 is a single position in the genome, in or near the near HMGB3P6 gene. Published research associates it with white blood cell count (neutrophil). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74117915 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74117915 come from?

GWAS Catalog, BMC genomics 2021, PMID:34107879. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White blood cell count (neutrophil) (rs74117915). MyGeneLog™. https://www.mygenelog.com/variants/rs74117915

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