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Total cholesterol levels

PPP6R2 · rs7410608

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0116 higher (95% confidence interval 0.0089-0.0144); p = 4 × 10−12.

How common The C allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 22, band 22q13.33 — in an intron of PPP6R2.

What each result means

C/C Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs7410608

What is rs7410608?

rs7410608 is a single position in the genome, in or near the PPP6R2 gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7410608 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7410608 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total cholesterol levels (rs7410608). MyGeneLog™. https://www.mygenelog.com/variants/rs7410608

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