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Serum levels of protein PTPRN2

near ATP5MC1P1 · rs74091228

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 5,368 Icelandic ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.703 higher (95% confidence interval 0.54-0.87); p = 3 × 10⁻¹⁷.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 14, band 14q32.33 — between genes, 1.4 kb from ATP5MC1P1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum levels of protein PTPRN2 compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum levels of protein PTPRN2.

G/G Published research associates this genotype with typical/baseline likelihood of Serum levels of protein PTPRN2 — no copies of the reported risk allele.

Source

A genome-wide association study of serum proteins reveals shared loci with common diseases

Gudjonsson A, Gudmundsdottir V, Axelsson GT, Gudmundsson EF, Jonsson BG, Launer LJ, Lamb JR, Jennings LL, Aspelund T, Emilsson V, Gudnason V

Nature communications · 2022 · PMID 35078996 · open access

Questions about rs74091228

What is rs74091228?

rs74091228 is a single position in the genome, in or near the near ATP5MC1P1 gene. Published research associates it with serum levels of protein ptprn2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74091228 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74091228 come from?

GWAS Catalog, Nature communications 2022, PMID:35078996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum levels of protein PTPRN2 (rs74091228). MyGeneLog™. https://www.mygenelog.com/variants/rs74091228

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