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Platelet count

TIE1 · rs74069551

Where this position leads

Condition: Blood Cell Counts

rs74069551 Condition: Blood Cell Counts Blood Cell Counts Condition rs74069551 rs74069551 TIE1

What the study found

Who was studied 15,171 African American or Afro-Caribbean and African ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.284 SD units lower (95% confidence interval 0.22-0.35); p = 8 × 10−17.

How common The G allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 1, band 1p34.2 — in an intron of TIE1.

What each result means

A/A No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs74069551

What is rs74069551?

rs74069551 is a single position in the genome, in or near the TIE1 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74069551 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs74069551 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74069551 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Platelet count (rs74069551). MyGeneLog™. https://www.mygenelog.com/variants/rs74069551

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