Standard

Systolic blood pressure

ZNF423 · rs7404754

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0098 lower (95% confidence interval 0.0067-0.0129); p = 3 × 10⁻¹⁰.

Where it sits Chromosome 16, band 16q12.1 — in an intron of ZNF423.

How common each version is

CT

Korean KRGDB

C 31.4% · T 68.6%

Korean Korea4K

C 32.8% · T 67.2%

Korean Korea1K

C 32.2% · T 67.8%

Japanese ToMMo

C 27.3% · T 72.7%

Vietnamese

C 49.5% · T 50.5%

World gnomAD

C 39.1% · T 60.9%

World 1000 Genomes

C 36.3% · T 63.7%

World TOPMed

C 38.7% · T 61.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures

Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P

Nature communications · 2025 · PMID 40436827 · open access

Questions about rs7404754

What is rs7404754?

rs7404754 is a single position in the genome, in or near the ZNF423 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7404754 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs7404754 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7404754 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Systolic blood pressure (rs7404754). MyGeneLog™. https://www.mygenelog.com/variants/rs7404754

← See all variants