NCK2 · rs73946302
Where this position leads
Condition: Alzheimer's Disease
What the study found
Who was studied 128,681 European ancestry cases, 849,833 European ancestry controls.
The effect Each copy of the G allele carried 0.88 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias (95% confidence interval 0.85-0.92); p = 1 × 10−10.
How common The G allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 2, band 2q12.2 — in an intron of NCK2.
rs73946302 is a single position in the genome, in or near the NCK2 gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs73946302). MyGeneLog™. https://www.mygenelog.com/variants/rs73946302