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Who was studied 474,237 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0225 SD unit lower (95% confidence interval 0.019-0.026); p = 1 × 10−29.
How common The C allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 22, band 22q12.2 — in an intron of LIMK2.
What each result means
C/CTwo copies of the version the research linked to Eosinophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Eosinophil count. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Eosinophil count. This is the starting point the study compared everyone against.
rs739427 is a single position in the genome, in or near the LIMK2 gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs739427 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs739427 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs739427 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 131129Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others9Total13Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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