Plasma metoprolol levels in chronic kidney disease
SEPTIN3 · rs739296
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 917 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.6 higher (95% confidence interval 0.43-0.77); p = 1 × 10−11.
How common The A allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 22, band 22q13.2 — in an intron of SEPTIN3.
What each result means
A/ATwo copies of the version the research linked to Plasma metoprolol levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Plasma metoprolol levels in chronic kidney disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Plasma metoprolol levels in chronic kidney disease. This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs739296
What is rs739296?
rs739296 is a single position in the genome, in or near the SEPTIN3 gene. Published research associates it with plasma metoprolol levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs739296 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs739296 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Plasma metoprolol levels in chronic kidney disease (rs739296). MyGeneLog™. https://www.mygenelog.com/variants/rs739296