Sensitive

Lung cancer in ever smokers

HLA-DOB · rs7383287

Where this position leads

What the study found

Who was studied 23,223 European ancestry cases, 16,964 European ancestry controls.

The effect Each copy of the G allele carried 1.12 times the odds of Lung cancer in ever smokers (95% confidence interval 1.082275651-1.160205575); p = 1 × 10⁻¹⁰.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — at a splice region of HLA-DOB.

What each result means

A/A No copy of the version the research linked to Lung cancer in ever smokers. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Lung cancer in ever smokers. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Lung cancer in ever smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A

and 128 more — show all

Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI

SpiroMeta Consortium

Nature genetics · 2017 · PMID 28604730 · open access

Questions about rs7383287

What is rs7383287?

rs7383287 is a single position in the genome, in or near the HLA-DOB gene. Published research associates it with lung cancer in ever smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7383287 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7383287 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7383287 come from?

GWAS Catalog, Nature genetics 2017, PMID:28604730. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung cancer in ever smokers (rs7383287). MyGeneLog™. https://www.mygenelog.com/variants/rs7383287

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