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Allergic disease (asthma, hay fever and/or eczema) (age of onset)

HLA-DPA1 · rs73739621

Where this position leads

Condition: Asthma

rs73739621 Condition: Asthma Asthma Condition rs73739621 rs73739621 HLA-DPA1

What the study found

Who was studied 117,130 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.051 lower (95% confidence interval 0.035-0.067); p = 4 × 10−11.

How common The C allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DPA1.

What each result means

C/C Two copies of the version the research linked to Allergic disease (asthma, hay fever and/or eczema) (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Allergic disease (asthma, hay fever and/or eczema) (age of onset). That is a smaller link than two copies.
T/T No copy of the version the research linked to Allergic disease (asthma, hay fever and/or eczema) (age of onset). This is the starting point the study compared everyone against.
Source
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Ferreira MAR, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, Lu Y, Grosche S, Rüschendorf F
and 28 more — show all
Granell R, Brumpton BM, Fritsche LG, Bhatta L, Gabrielsen ME, Nielsen JB, Zhou W, Hveem K, Langhammer A, Holmen OL, Løset M, Abecasis GR, Willer CJ, Emami NC, Cavazos TB, Witte JS, Szwajda A, Hinds DA, Hübner N, Weidinger S, Magnusson PK, Jorgenson E, Karlsson R, Paternoster L, Boomsma DI, Almqvist C, Lee YA, Koppelman GH
23andMe Research Team · collaborators of the SHARE study
PLoS genetics · 2020 · PMID 32603359 · open access

Questions about rs73739621

What is rs73739621?

rs73739621 is a single position in the genome, in or near the HLA-DPA1 gene. Published research associates it with allergic disease (asthma, hay fever and/or eczema) (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73739621 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs73739621 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73739621 come from?

GWAS Catalog, PLoS genetics 2020, PMID:32603359. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Allergic disease (asthma, hay fever and/or eczema) (age of onset) (rs73739621). MyGeneLog™. https://www.mygenelog.com/variants/rs73739621

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