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Who was studied 43,639 European ancestry cases, 506,798 European ancestry controls; replicated in 1,089 cases, 5,228 controls.
The effect
Each copy of the T allele carried 1.05 times the odds of Gallstone disease (95% confidence interval 1.04-1.06); p = 9 × 10−11.
Where it sits Chromosome 2, band 2q35 — between genes, 1.2 kb from ARPC2.
What each result means
C/CNo copy of the version the research linked to Gallstone disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Gallstone disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Gallstone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs736730 is a single position in the genome, in or near the near ARPC2 gene. Published research associates it with gallstone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs736730 linked to?
On MyGeneLog this position is linked to Gallstone Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs736730 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs736730 come from?
GWAS Catalog, Hepatology (Baltimore, Md.) 2022, PMID:34651315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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