Standard

Concentration of very small VLDL particles

ST3GAL4 · rs73632737

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the C allele shifted the measure 0.03 mmol/L higher (95% confidence interval 0.03-0.03); p = 5 × 10⁻¹².

Where it sits Chromosome 11, band 11q24.2 — in an intron of ST3GAL4.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Concentration of very small VLDL particles compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Concentration of very small VLDL particles.

G/G Published research associates this genotype with typical/baseline likelihood of Concentration of very small VLDL particles — no copies of the reported risk allele.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs73632737

What is rs73632737?

rs73632737 is a single position in the genome, in or near the ST3GAL4 gene. Published research associates it with concentration of very small vldl particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73632737 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs73632737 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73632737 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Concentration of very small VLDL particles (rs73632737). MyGeneLog™. https://www.mygenelog.com/variants/rs73632737

← See all variants