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Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls.
The effect
Each copy of the A allele shifted the measure 0.0663 higher (95% confidence interval 0.047-0.085); p = 5 × 10−12.
Where it sits Chromosome 17, band 17p13.1 — a synonymous change in EIF4A1.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-12-17.
ClinVar record 1328715NM_001416.4(EIF4A1):c.267G>A (p.Ser89=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40050615 · open access
Questions about rs7358
What is rs7358?
rs7358 is a single position in the genome, in or near the EIF4A1 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7358 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs7358 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7358 come from?
GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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