Gene Knowledge Graph
UTC
Sensitive

Multiple sclerosis

PRNCR1 · rs735542

Where this position leads

Condition: Multiple Sclerosis

rs735542 Condition: Multiple Sclerosis Multiple Sclerosis Condition rs735542 rs735542 PRNCR1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Multiple sclerosis compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Multiple sclerosis.
G/G Published research associates this genotype with typical/baseline likelihood of Multiple sclerosis — no copies of the reported risk allele.
Source
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium
Science (New York, N.Y.) · 2019 · PMID 31604244

Questions about rs735542

What is rs735542?

rs735542 is a single position in the genome, in or near the PRNCR1 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs735542 linked to?

On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs735542 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs735542 come from?

GWAS Catalog, Science 2019, PMID:31604244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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