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Who was studied 575,531 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0175 lower (95% confidence interval 0.014-0.021); p = 6 × 10−18.
Where it sits Chromosome 8, band 8p23.1 — in an intron of PPP1R3B-DT.
What each result means
A/ATwo copies of the version the research linked to C-reactive protein levels (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to C-reactive protein levels (MTAG). That is a smaller link than two copies.
C/CNo copy of the version the research linked to C-reactive protein levels (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 36376304 · open access
Questions about rs735449
What is rs735449?
rs735449 is a single position in the genome, in or near the PPP1R3B-DT gene. Published research associates it with c-reactive protein levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs735449 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs735449 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs735449 come from?
GWAS Catalog, Nature communications 2022, PMID:36376304. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels (MTAG) (rs735449). MyGeneLog™. https://www.mygenelog.com/variants/rs735449