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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 6,148 African American individuals.
The effect
Each copy of the A allele shifted the measure 3.25 lower (95% confidence interval 2.88-3.61); p = 6 × 10−69.
How common The A allele had a frequency of about 82% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — between genes, 0.1 kb from CREB3L3.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-05-11.
ClinVar record 1239511NC_000019.10:g.4153569A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to DNA methylation PhenoAge acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to DNA methylation PhenoAge acceleration. That is a smaller link than two copies.
G/GNo copy of the version the research linked to DNA methylation PhenoAge acceleration. This is the starting point the study compared everyone against.
Genome biology · 2021 · PMID 34187551 · open access
Questions about rs73538174
What is rs73538174?
rs73538174 is a single position in the genome, in or near the near CREB3L3 gene. Published research associates it with dna methylation phenoage acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs73538174 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73538174 come from?
GWAS Catalog, Genome biology 2021, PMID:34187551. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
DNA methylation PhenoAge acceleration (rs73538174). MyGeneLog™. https://www.mygenelog.com/variants/rs73538174