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Neuroticism

near CLP1 · rs73480560

Where this position leads

Conditions: Neuroticism, Post-Traumatic Stress Disorder (PTSD)

rs73480560 Condition: Neuroticism Neuroticism Condition Condition: Post-Traumatic Stress Disorder (PTSD) Post-Traumatic Stress Disorder (PTSD) Condition rs73480560 rs73480560 near CLP1

What the study found

Who was studied 449,484 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 5.99 z score higher (95% confidence interval -); p = 2 × 10−9.

Where it sits Chromosome 11, band 11q12.1 — between genes, 4.1 kb from MIR130AHG.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population.
Source
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, White T, Tiemeier H
and 6 more — show all
Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D
23andMe Research Team
Nature genetics · 2018 · PMID 29942085

Questions about rs73480560

What is rs73480560?

rs73480560 is a single position in the genome, in or near the near CLP1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73480560 linked to?

On MyGeneLog this position is linked to Neuroticism, Post-Traumatic Stress Disorder (PTSD). The research behind each link, and its sources, are set out on that condition page.

Does having rs73480560 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73480560 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs73480560). MyGeneLog™. https://www.mygenelog.com/variants/rs73480560

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