Sensitive

Temporomandibular joint disorder

DMD · rs73460075

Where this position leads

Condition: Temporomandibular Joint Disorder

What the study found

Who was studied 769 Hispanic cases, 9,384 Hispanic controls; replicated in 768 European ancestry cases, 4,845 European ancestry controls, 144 Hispanic/Latin American cases, 492 Hispanic/Latin American controls, 999 cases, 2,031 controls.

The effect Each copy of the C allele carried 1.78 times the odds of Temporomandibular joint disorder (95% confidence interval -); p = 4 × 10⁻⁸.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome X, band Xp21.1 — in an intron of DMD.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Temporomandibular joint disorder compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Temporomandibular joint disorder.

G/G Published research associates this genotype with typical/baseline likelihood of Temporomandibular joint disorder — no copies of the reported risk allele.

Source

GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos

Sanders AE, Jain D, Sofer T, Kerr KF, Laurie CC, Shaffer JR, Marazita ML, Kaste LM, Slade GD, Fillingim RB, Ohrbach R, Maixner W

and 15 more — show all

Kocher T, Bernhardt O, Teumer A, Schwahn C, Sipilä K, Lähdesmäki R, Männikkö M, Pesonen P, Järvelin M, Rizzatti-Barbosa CM, Meloto CB, Ribeiro-Dasilva M, Diatchenko L, Serrano P, Smith SB

Journal of dental research · 2017 · PMID 28081371

Questions about rs73460075

What is rs73460075?

rs73460075 is a single position in the genome, in or near the DMD gene. Published research associates it with temporomandibular joint disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73460075 linked to?

On MyGeneLog this position is linked to Temporomandibular Joint Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs73460075 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73460075 come from?

GWAS Catalog, J Dent Res 2017, PMID:28081371. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Temporomandibular joint disorder (rs73460075). MyGeneLog™. https://www.mygenelog.com/variants/rs73460075

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