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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 95,395 European ancestry cases, 1,011,691 European ancestry controls, 65 East Asian ancestry cases, 2,619 East Asian ancestry controls, 1,357 African or African American cases, 21,394 African or African American controls, 76 South Asian ancestry cases, 7,921 South Asian ancestry controls, 288 Hispanic cases, 3,486 Hispanic controls, 147 Admixed ancestry cases, 8,268 Admixed ancestry controls.
The effect
Each copy of the A allele carried 1.04 times the odds of Osteoarthritis (hip) (95% confidence interval 1.02940426559897-1.05804170143041); p = 1 × 10−9.
How common The A allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 6, band 6p21.1 — between genes, 90.7 kb from RUNX2.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis (hip). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Osteoarthritis (hip). That is a smaller link than two copies.
C/CNo copy of the version the research linked to Osteoarthritis (hip). This is the starting point the study compared everyone against.
rs73450758 is a single position in the genome, in or near the near RUNX2 gene. Published research associates it with osteoarthritis (hip). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73450758 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs73450758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73450758 come from?
GWAS Catalog, Nature 2025, PMID:40205036. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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