Sensitive

Alzheimer's disease, proxy Alzheimer's disease or related dementias

near TREM2 · rs73427293

Where this position leads

Condition: Alzheimer's Disease

rs73427293 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs73427293 rs73427293 near TREM2

What the study found

Who was studied 6,796 African American cases, 4,385 African American maternal cases, 2,256 African American paternal cases, 69,627 African American controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 3 × 10−9.

Where it sits Chromosome 6, band 6p21.1 — between genes, 5.7 kb from TREM2.

What each result means

A/A Two copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is a smaller link than two copies.
T/T No copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
Source

Questions about rs73427293

What is rs73427293?

rs73427293 is a single position in the genome, in or near the near TREM2 gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73427293 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs73427293 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73427293 come from?

GWAS Catalog, Molecular psychiatry 2023, PMID:36543923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs73427293). MyGeneLog™. https://www.mygenelog.com/variants/rs73427293

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