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Who was studied 57,564 European ancestry cases, 256,395 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 5.82 lower; p = 6 × 10−9.
How common The A allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 15, band 15q21.1 — in an intron of SEMA6D.
What each result means
A/ATwo copies of the version the research linked to Alcohol use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alcohol use disorder. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alcohol use disorder. This is the starting point the study compared everyone against.
Nature neuroscience · 2020 · PMID 32451486 · open access
Questions about rs73403005
What is rs73403005?
rs73403005 is a single position in the genome, in or near the SEMA6D gene. Published research associates it with alcohol use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73403005 linked to?
On MyGeneLog this position is linked to Alcohol Use Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs73403005 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73403005 come from?
GWAS Catalog, Nature neuroscience 2020, PMID:32451486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alcohol use disorder (rs73403005). MyGeneLog™. https://www.mygenelog.com/variants/rs73403005