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IgG glycosylation patterns

CHCHD10 · rs73396548

Where this position leads

What the study found

Who was studied 1,823 European ancestry individuals; replicated in 1,836 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.329 lower (95% confidence interval 0.22-0.43); p = 7 × 10⁻¹⁰.

How common The A allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 22, band 22q11.23 — in an intron of CHCHD10.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2019-04-04. ClinVar record 1250749 NM_213720.3(CHCHD10):c.261+276C>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to IgG glycosylation patterns. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to IgG glycosylation patterns. That is a smaller link than two copies.

G/G No copy of the version the research linked to IgG glycosylation patterns. This is the starting point the study compared everyone against.

Source

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

Wahl A, van den Akker E, Klaric L, Štambuk J, Benedetti E, Plomp R, Razdorov G, Trbojević-Akmačić I, Deelen J, van Heemst D, Slagboom PE, Vučković F

and 10 more — show all

Grallert H, Krumsiek J, Strauch K, Peters A, Meitinger T, Hayward C, Wuhrer M, Beekman M, Lauc G, Gieger C

Frontiers in immunology · 2018 · PMID 29535710 · open access

Questions about rs73396548

What is rs73396548?

rs73396548 is a single position in the genome, in or near the CHCHD10 gene. Published research associates it with igg glycosylation patterns. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73396548 linked to?

On MyGeneLog this position is linked to IgG Glycosylation. The research behind each link, and its sources, are set out on that condition page.

Does having rs73396548 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73396548 come from?

GWAS Catalog, Frontiers in immunology 2018, PMID:29535710. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

IgG glycosylation patterns (rs73396548). MyGeneLog™. https://www.mygenelog.com/variants/rs73396548

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