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Circulating plasma alpha-Klotho levels

near TOMM22P3 · rs7333961

What the study found

Who was studied 4,376 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.327 z score lower (95% confidence interval 0.23-0.43); p = 2 × 10−10.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 13, band 13q13.1 — between genes, 4.7 kb from TOMM22P3.

What each result means

A/A Two copies of the version the research linked to Circulating plasma alpha-Klotho levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Circulating plasma alpha-Klotho levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Circulating plasma alpha-Klotho levels. This is the starting point the study compared everyone against.
Source

Questions about rs7333961

What is rs7333961?

rs7333961 is a single position in the genome, in or near the near TOMM22P3 gene. Published research associates it with circulating plasma alpha-klotho levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7333961 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7333961 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:34542150. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Circulating plasma alpha-Klotho levels (rs7333961). MyGeneLog™. https://www.mygenelog.com/variants/rs7333961

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