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Spontaneous coronary artery dissection

COL4A1 · rs7326444

What the study found

Who was studied 1,917 European ancestry cases, 9,292 European ancestry controls.

The effect Each copy of the G allele carried 1.31 times the odds of Spontaneous coronary artery dissection (95% confidence interval 1.21-1.42); p = 1 × 10−10.

How common The G allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 13, band 13q34 — in an intron of COL4A1.

What each result means

A/A No copy of the version the research linked to Spontaneous coronary artery dissection. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Spontaneous coronary artery dissection. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Spontaneous coronary artery dissection. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7326444

What is rs7326444?

rs7326444 is a single position in the genome, in or near the COL4A1 gene. Published research associates it with spontaneous coronary artery dissection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7326444 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7326444 come from?

GWAS Catalog, Nature genetics 2023, PMID:37248441. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Spontaneous coronary artery dissection (rs7326444). MyGeneLog™. https://www.mygenelog.com/variants/rs7326444

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