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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 313,372 European ancestry individuals, 5,573 African ancestry individuals, 6,689 South Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0577 higher (95% confidence interval 0.042-0.073); p = 1 × 10−13.
Where it sits Chromosome 12, band 12q24.31 — in an intron of SCARB1.
What each result means
A/ATwo copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
C/CNo copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs73227581
What is rs73227581?
rs73227581 is a single position in the genome, in or near the SCARB1 gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs73227581 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73227581 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
High density lipoprotein cholesterol levels (rs73227581). MyGeneLog™. https://www.mygenelog.com/variants/rs73227581