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Serum phosphate levels

CPNE4 · rs73222317

Where this position leads

Condition: Gout

rs73222317 Condition: Gout Gout Condition rs73222317 rs73222317 CPNE4

What the study found

Who was studied 312,888 European ancestry individuals, 5,568 African ancestry individuals, 6,685 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.022 higher (95% confidence interval 0.015-0.029); p = 2 × 10−9.

Where it sits Chromosome 3, band 3q22.1 — in an intron of CPNE4.

What each result means

A/A Two copies of the version the research linked to Serum phosphate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Serum phosphate levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Serum phosphate levels. This is the starting point the study compared everyone against.
Source

Questions about rs73222317

What is rs73222317?

rs73222317 is a single position in the genome, in or near the CPNE4 gene. Published research associates it with serum phosphate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73222317 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs73222317 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73222317 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum phosphate levels (rs73222317). MyGeneLog™. https://www.mygenelog.com/variants/rs73222317

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