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Who was studied 12.945 European ancestry cases, 274,252 European ancestry controls; replicated in 4,242 European ancestry cases, 12,802 European ancestry controls.
The effect
Each copy of the G allele carried 1.11 times the odds of Basal cell carcinoma; p = 2 × 10−13.
How common The G allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — between genes, 40.5 kb from CUX1.
What each result means
A/ANo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2016 · PMID 27539887 · open access
Questions about rs73183643
What is rs73183643?
rs73183643 is a single position in the genome, in or near the CUX1 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73183643 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs73183643 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73183643 come from?
GWAS Catalog, Nat Commun 2016, PMID:27539887. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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